Sodium selenite and cancer related lymphedema: Biological and pharmacological effects.
Identifieur interne : 000B00 ( Main/Exploration ); précédent : 000A99; suivant : 000B01Sodium selenite and cancer related lymphedema: Biological and pharmacological effects.
Auteurs : Christina Pfister [Allemagne] ; Horst Dawzcynski [Allemagne] ; Franz-Josef Schingale [Allemagne]Source :
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [ 1878-3252 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anti-inflammatoires non stéroïdiens (), Anti-inflammatoires non stéroïdiens (pharmacologie), Anti-inflammatoires non stéroïdiens (usage thérapeutique), Complexe glycoprotéique GPIb-IX plaquettaire (biosynthèse), Espèces réactives de l'oxygène (métabolisme), Humains, Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Lymphoedème (traitement médicamenteux), Sélénite de sodium (), Sélénite de sodium (pharmacologie), Sélénite de sodium (usage thérapeutique), Techniques de physiothérapie.
- MESH :
- anatomopathologie : Lymphoedème.
- biosynthèse : Complexe glycoprotéique GPIb-IX plaquettaire.
- métabolisme : Espèces réactives de l'oxygène, Lymphoedème.
- pharmacologie : Anti-inflammatoires non stéroïdiens, Sélénite de sodium.
- traitement médicamenteux : Lymphoedème.
- usage thérapeutique : Anti-inflammatoires non stéroïdiens, Sélénite de sodium.
- Animaux, Anti-inflammatoires non stéroïdiens, Humains, Sélénite de sodium, Techniques de physiothérapie.
English descriptors
- KwdEn :
- Animals, Anti-Inflammatory Agents, Non-Steroidal (chemistry), Anti-Inflammatory Agents, Non-Steroidal (pharmacology), Anti-Inflammatory Agents, Non-Steroidal (therapeutic use), Humans, Lymphedema (drug therapy), Lymphedema (metabolism), Lymphedema (pathology), Physical Therapy Modalities, Platelet Glycoprotein GPIb-IX Complex (biosynthesis), Reactive Oxygen Species (metabolism), Sodium Selenite (chemistry), Sodium Selenite (pharmacology), Sodium Selenite (therapeutic use).
- MESH :
- chemical , biosynthesis : Platelet Glycoprotein GPIb-IX Complex.
- chemical , chemistry : Anti-Inflammatory Agents, Non-Steroidal, Sodium Selenite.
- chemical , metabolism : Reactive Oxygen Species.
- chemical , pharmacology : Anti-Inflammatory Agents, Non-Steroidal, Sodium Selenite.
- chemical , therapeutic use : Anti-Inflammatory Agents, Non-Steroidal, Sodium Selenite.
- drug therapy : Lymphedema.
- metabolism : Lymphedema.
- pathology : Lymphedema.
- Animals, Humans, Physical Therapy Modalities.
Abstract
A significant percentage of cancer patients develop secondary lymphedema after surgery or radiotherapy. The preferred treatment of secondary lymphedema is complex physical therapy. Pharmacotherapy, for example with diuretics, has received little attention, because they were not effective and only offered short-term solutions. Sodium selenite showed promise as a cost-effective, nontoxic anti-inflammatory agent. Treatment with sodium selenite lowers reactive oxygen species (ROS) production, causes a spontaneous reduction in lymphedema volume, increases the efficacy of physical therapy for lymphedema, and reduces the incidence of erysipelas infections in patients with chronic lymphedema. Besides biological effects in reducing excessive production of ROS, sodium selenite also displays various pharmacological effects. So far the exact mechanisms of these pharmacological effects are mostly unknown, but probably include inhibition of adhesion protein expression.
DOI: 10.1016/j.jtemb.2016.05.005
PubMed: 27267968
Affiliations:
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Le document en format XML
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stéroïdiens (usage thérapeutique)</term><term>Complexe glycoprotéique GPIb-IX plaquettaire (biosynthèse)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Humains</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (métabolisme)</term><term>Lymphoedème (traitement médicamenteux)</term><term>Sélénite de sodium ()</term><term>Sélénite de sodium (pharmacologie)</term><term>Sélénite de sodium (usage thérapeutique)</term><term>Techniques de physiothérapie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Platelet Glycoprotein GPIb-IX Complex</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Sodium Selenite</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Sodium Selenite</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Sodium Selenite</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Complexe glycoprotéique GPIb-IX plaquettaire</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-inflammatoires non stéroïdiens</term><term>Sélénite de sodium</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anti-inflammatoires non stéroïdiens</term><term>Sélénite de sodium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Physical Therapy Modalities</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anti-inflammatoires non stéroïdiens</term><term>Humains</term><term>Sélénite de sodium</term><term>Techniques de physiothérapie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A significant percentage of cancer patients develop secondary lymphedema after surgery or radiotherapy. The preferred treatment of secondary lymphedema is complex physical therapy. Pharmacotherapy, for example with diuretics, has received little attention, because they were not effective and only offered short-term solutions. Sodium selenite showed promise as a cost-effective, nontoxic anti-inflammatory agent. Treatment with sodium selenite lowers reactive oxygen species (ROS) production, causes a spontaneous reduction in lymphedema volume, increases the efficacy of physical therapy for lymphedema, and reduces the incidence of erysipelas infections in patients with chronic lymphedema. Besides biological effects in reducing excessive production of ROS, sodium selenite also displays various pharmacological effects. So far the exact mechanisms of these pharmacological effects are mostly unknown, but probably include inhibition of adhesion protein expression.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Stuttgart</li></region><settlement><li>Stuttgart</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Pfister, Christina" sort="Pfister, Christina" uniqKey="Pfister C" first="Christina" last="Pfister">Christina Pfister</name></region><name sortKey="Dawzcynski, Horst" sort="Dawzcynski, Horst" uniqKey="Dawzcynski H" first="Horst" last="Dawzcynski">Horst Dawzcynski</name><name sortKey="Schingale, Franz Josef" sort="Schingale, Franz Josef" uniqKey="Schingale F" first="Franz-Josef" last="Schingale">Franz-Josef Schingale</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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